تحقيق آماده در مورد بيحسي موضعي Local Anesthetics در قالب فايل پاورپوينت

توضیحات کامل در مورد فایل

دانلود تحقيق آماده در مورد بيحسي موضعي Local Anesthetics در قالب فايل پاورپوينت با قابليت ويرايش

توضيحات تحقيق آماده در مورد بيحسي موضعي Local Anesthetics
عنوان: بيحسي موضعي Local Anesthetics
فرمت: POWERPOINT پاورپونت (قابل ويرايش)
چاپ : بدون هيچ گونه مشکل در پرينت گرفتن
تعداد اسلايد: 39 اسلايد قابل ويرايش
زبان : انگليسي

اسکرين شات تحقيق آماده در مورد بيحسي موضعي Local Anesthetics

 

قسمتي از مطالب تحقيق در مورد بيحسي موضعي Local Anesthetics :

 

Block conduction of pain impulses in the periphery i.e. prior to spinal cord (in a specific region of the body)
Consciousness maintained
Normally, the process is completely reversible--the agent does not produce any residual effect on the nerve fiber
Blockade of Voltage gated Na+ channels (Nav)
Nav
Present in all neurons
Nav Also present in other depolarizing cell types (muscle)
Nav Responsible for main depolarizing current of action potentials
? Block Nav, block all action potentials and all neuronal conduction

Cocaine:

The first local anesthetic was Cocaine which was isolated from coca leaves by Albert Niemann in Germany in the 1860s
It was introduced into clinical use by Koller in 1884 as an ophthalmic anesthetic
Also in 1884, Dr. William Stewart Halsted was the first to describe the injection of cocaine into a sensory nerve trunk to create surgical anesthesia
Cocaine was soon found to be strongly addicting but was widely used, nevertheless, for 30 years, since it was the only local anesthetic drug available
In an attempt to improve the properties of cocaine, Einhorn in 1905 synthesized procaine, which became the dominant local anesthetic for the next 50 years
Lidocaine, still a popular agent, was synthesized in 1943 by L?fgren and may be considered the prototype local anesthetic agent
Nav , LA must each be in a specific state
Nav must be in ‘open’ or ‘inactivated state’
LA – must be in ionized (+ charged) form
This is critical to understanding LA action
3 - Amide or ester linkage

Ester :

hydrolysed by plasma & liver esterases
shorter acting - less systemic distribution
They are hydrolyzed in plasma by pseudo-cholinesterase
One of the by-products of metabolism is para-aminobenzoic acid, the common cause of allergic reactions seen with these agents
Cocaine, Procaine, Benzocaine, Tetracaine, Chloroprocaine

دوستان مي توانيد اين تحقيق در مورد بيحسي موضعي Local Anesthetics را بصورت کامل و با قابليت ويرايش از سایت یکتا فایل دريافت نمايد بعد دانلود لينک دانلود در پنل کاربري شما بصورت خودکار قرار مي گيرد و با خيال راحت مي توانيد محصول دانلودی خود را دانلود نماييد در صورت پیشنهاد داشتن مي توانيد از قسمت نظرات بپرسيد